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Compared with the previously published articles, thecontents and purposes of this review are different: (1) Focusing on the therapeutic roles of GLP-1RAs in T2DM, the multiple pathways by which GLP-1 regulates blood glucose are described in a more comprehensive and in-depth manner at the mechanism level

MF conceived, organized, wrote and revised the whole manuscript

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Eric Topol's 2025 review of the peptide evidence described ipamorelin and related compounds as carrying 'the potential risk of cancer' on that mechanistic basis

SNI-induced pain Under continuous anesthesia with isoflurane, mice underwent surgical manipulation to expose the left sciatic nerve by separating the muscle tissue